Addition of native vitamin D (eg, cholecalciferol or ergocalciferol) may be considered for supplemental therapy. Based on the Endocrine Society guidelines for the Management of Hypoparathyroidism, active vitamin D preparations (ie, alfacalcidol, calcitriol) in conjunction with calcium supplementation is the standard therapy for hypoparathyroidism. Since parathyroid hormone (PTH) is required for the conversion of vitamin D (ergocalciferol or cholecalciferol) to the active metabolite of vitamin D (1,25-dihydroxyvitamin D), alternative vitamin D preparations not dependent on this conversion (eg, alfacalcidol, calcitriol) are recommended for routine use.
Inactive until hydroxylated hepatically to 25-hydroxyvitamin D then renally to the active metabolite 1,25-dihydroxyvitamin D (calcitriol) (IOM 2011) ExcretionĬirculating: 25(OH)D: 2 to 3 weeks 1,25-dihydroxyvitamin D: ~4 hours Use: Labeled Indicationsĭietary supplement: As a vitamin D dietary supplement Off Label Uses Hypoparathyroidism
The active metabolite, 1,25-dihydroxyvitamin D (calcitriol), stimulates calcium and phosphate absorption from the small intestine, promotes secretion of calcium from bone to blood promotes renal tubule phosphate resorption (IOM 2011) Metabolism Tablet Chewable, Oral :ĭetailed Cholecalciferol dosage information Brand Names: U.S.Ĭholecalciferol (vitamin D 3) is a provitamin. Vitamin D3 Ultra Potency: 1250 mcg (50000 unit) Vitamin D3 Super Strength: 50 mcg (2000 unit) Pronutrients Vitamin D3: 25 mcg (1000 unit)
Last updated on Sep 1, 2021.Įxcipient information presented when available (limited, particularly for generics) consult specific product labeling.
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